VDR Functions

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VDR Functions

VDR Functions

Virtual Data Rooms are utilized by law firms, CPAs and accounting firms to collect, organize and manage client documentation for audit and tax preparation. Banks and mortgage brokers also make use of vdrs to collect documents, organize them and share them with clients and other parties. Investment banking processes such as IPOs capital raising, M&A are likely to require massive amounts of information sharing, which a VDR is well-equipped to handle.

The VDR undergoes a variety of post-translational modifications that regulate its function. These modifications include the binding domain, activation function 2(AF-2), and dimerization interface. One of these modifications, phosphorylation of position 51 in serine, has been found to be essential in 1,25(OH2D)-dependent transcriptional activity. In in vitro, mutation of this serine residue into glycine reduced the 1,25(OH2)2D-induced transcriptional activation. This mutation did not affect PKC B-catalyzed Phosphorylation in the HL-60 cells, and did significantly change the AF-2 or Dimerization process when 1,25(OH2)2D or Cytosolic calcium was present.

Unliganded DR has been proven to interact with chromatin and promote the initiation of cWnt and the sonic hedgehog gene in keratinocytes. Loss of VDR in animals leads to hair follicle dysfunction, which includes the alopecia. Many studies have attempted correlation of RFLPs with specific RFLPs or single nucleotide differences within or near the VDR genes with clinical characteristics. However, these studies have only provided a sliver of insight into the relationship between gene expression and clinical disease.

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